A new phenolic glycoside from Lindera nacusua.

Jie-Ping Lei, Guo-Qing Wei, Juan-Juan Yuan, Kang-Zhi Tan, Qiao-Yu Chen, Tao Zhang, Chao-Ying Ma, He-Zhong Jiang

Natural product research 2017 Apr

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The present study was designed to investigate the chemical constituents of Lindera nacusua and their antitumor activities. A new phenolic glycoside, namely 1-O-3-hydroxyphenyl-5-methoxyphenol-(6'-O-vanilloyl)-β-d-glucopyranoside (1), together with five known phenolic glycosides (2-6), two anthraquinones (7, 8) and two γ-butanolides (9, 10), was isolated, and its structure was elucidated by spectroscopic and chemical methods. Compounds 1-10 were screened for their in vitro cytotoxicities against HL-60, SMMC-7721, A549, MCF-3 and SW480 cell lines by the MTS method. Compounds 9 and 10 showed moderate cytotoxicities with IC50 values ranging from 17.40 to 35.21 μM.

Citation

Jie-Ping Lei, Guo-Qing Wei, Juan-Juan Yuan, Kang-Zhi Tan, Qiao-Yu Chen, Tao Zhang, Chao-Ying Ma, He-Zhong Jiang. A new phenolic glycoside from Lindera nacusua. Natural product research. 2017 Apr;31(8):896-901