Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Cells receive many different environmental clues to which they must adapt accordingly. Therefore, a complex signal transduction network has evolved. Cellular signal transduction is a highly dynamic process, in which the specific outcome is a result of the exact spatial and temporal resolution of single sub-events. While conventional techniques, like chemical inducer systems, have led to a sound understanding of the architecture of signal transduction pathways, the spatiotemporal aspects were often impossible to resolve. Optogenetics, based on genetically encoded light-responsive proteins, has the potential to revolutionize manipulation of signal transduction processes. Light can be easily applied with highest precision and minimal invasiveness. This review focuses on examples of optogenetic systems which were generated and applied to manipulate non-neuronal mammalian signaling processes at various stages of signal transduction, from cell membrane through cytoplasm to nucleus. Further, the future of optogenetic signaling will be discussed. Copyright © 2016 Elsevier B.V. All rights reserved.


Wignand W D Mühlhäuser, Adrian Fischer, Wilfried Weber, Gerald Radziwill. Optogenetics - Bringing light into the darkness of mammalian signal transduction. Biochimica et biophysica acta. 2017 Feb;1864(2):280-292

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 27845208

View Full Text