Correlation Engine 2.0
Clear Search sequence regions


  • acids (4)
  • canola oil (4)
  • cholesterol (4)
  • diet (11)
  • diet renal (1)
  • fat pads (3)
  • had (2)
  • hyperphagia (1)
  • lipid (3)
  • male (2)
  • obesity (1)
  • oxygen (2)
  • plant oils (2)
  • random (1)
  • rats (7)
  • renal function (2)
  • species (2)
  • weight (3)
  • Sizes of these terms reflect their relevance to your search.

    We investigated the effect of a canola oil-supplemented diet on the metabolic state and diabetic renal function of a type I diabetes experimental model. Male Sprague-Dawley rats were randomly divided into four groups: (1) normoglycemic+chow diet, (2) normoglycemic+a canola oil-supplemented chow diet, (3) diabetic+chow diet, and (4) diabetic+a canola oil-supplemented chow diet. For 15 weeks, animals were fed a diet of Purina rat chow alone or supplemented with 30% canola oil. Energetic intake, water intake, body weight, and adipose tissue fat pad were measured; renal function, electrolyte balance, glomerular filtration rate, and the plasmatic concentration of free fatty acids, cholesterol, triglycerides, and glucose were evaluated. The mesenteric, retroperitoneal, and epididymal fat pads were dissected and weighed. The kidneys were used for lipid peroxidation (LP) and reactive oxygen species (ROS) quantifications. Diabetic rats fed with a canola oil-supplemented diet had higher body weights, were less hyperphagic, and their mesenteric, retroperitoneal, and epididymal fat pads weighed more than diabetic rats on an unsupplemented diet. The canola oil-supplemented diet decreased plasmatic concentrations of free fatty acids, triglycerides, and cholesterol; showed improved osmolarity, water clearances, and creatinine depuration; and had decreased LP and ROS. A canola oil-supplemented diet decreases hyperphagia and prevents lipotoxicity and renal dysfunction in a type I diabetes mellitus model.

    Citation

    Edgar Cano-Europa, Rocio Ortiz-Butron, Estela Melendez Camargo, María Miriam Esteves-Carmona, Rosa Maria Oliart-Ros, Vanessa Blas-Valdivia, Margarita Franco-Colin. A Canola Oil-Supplemented Diet Prevents Type I Diabetes-Caused Lipotoxicity and Renal Dysfunction in a Rat Model. Journal of medicinal food. 2016 Nov;19(11):1041-1047

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 27845866

    View Full Text