Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Here, we report that the autophagy receptor and substrate p62/SQSTM1 inhibits DNA double-strand break -induced histone and chromatin ubiquitination, which has a critical role in attracting key repair factors to the break sites.
Yanan Wang, Wei-Guo Zhu, Ying Zhao. Autophagy regulates DNA repair by modulating histone ubiquitination. Molecular & cellular oncology. 2016;3(5):e1214772
PMID: 27857976
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