Autophagy regulates DNA repair by modulating histone ubiquitination.

Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Here, we report that the autophagy receptor and substrate p62/SQSTM1 inhibits DNA double-strand break -induced histone and chromatin ubiquitination, which has a critical role in attracting key repair factors to the break sites.

Citation

Yanan Wang, Wei-Guo Zhu, Ying Zhao. Autophagy regulates DNA repair by modulating histone ubiquitination. Molecular & cellular oncology. 2016;3(5):e1214772

PMID: 27857976

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