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To investigate the expression of Treg and IL-15 in the peripheral blood of patients with oral lichen planus (OLP). The peripheral blood was obtained from 36 OLP patients and 20 healthy controls. Flow cytometry was used to evaluate the proportion of Treg cells, and the level of IL-15 was measured by ELISA. The data were analyzed by SPSS 16.0 software package. In the peripheral blood of OLP patients, the proportion of CD4+CD25+Foxp3+ Treg cells and IL-15 content were significantly higher than those of the healthy controls (P<0.05), but there were no significantly difference between two clinical subtypes of OLP(P>0.05). The proportion of CD4+CD25+Foxp3+Treg cells was positively correlated with the level of IL-15(r=0.70,P<0.05). The high expression of Treg cells and IL-15 in the perpheral blood of OLP patients may be responsible for the pathogenesis of OLP.


Cui-Jie Wang, Yan-Jun Li, Jiang-Nan Xue, Hao-Su Ci, Li-Ping Li, Ling Li. Correlation of Treg and IL-15 expression in the peripheral blood of patients with oral lichen planus]. Shanghai kou qiang yi xue = Shanghai journal of stomatology. 2016 Aug;25(4):438-442

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PMID: 27858066

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