Thiol/disulfide homeostasis in postmenopausal osteoporosis.

V Korkmaz, Z Kurdoglu, M Alisik, E Turgut, O O Sezgın, H Korkmaz, Y Ergun, O Erel

Journal of endocrinological investigation 2017 Apr

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To evaluate the impact of postmenopausal osteoporosis on thiol/disulfide homeostasis. A total of 75 participants were divided into two groups: Group 1 (n = 40) was composed of healthy postmenopausal women, and group 2 (n = 35) was composed of women with postmenopausal osteoporosis. Clinical findings and thiol/disulfide homeostasis were compared between the two groups. The disulfide/native thiol ratio was 8.6% ± 3.6 in group 1 and 12.7% ± 8.4 in group 2 (p = 0.04). The disulfide/native thiol percent ratio was significantly higher in group 2 after adjustment for the years since menopause and age (p < 0.05). The native thiol/total thiol percent ratio was 85.6% ± 4.8 in group 1 and 73.8% ± 24.9 in group 2 (p = 0.01). The native thiol/total thiol percent ratio was significantly lower in group 2 after adjustment for the years since menopause and age (p < 0.05). Thiol/disulfide homeostasis shifted to the disulfide side independent of age and years since menopause in postmenopausal osteoporosis.

Citation

V Korkmaz, Z Kurdoglu, M Alisik, E Turgut, O O Sezgın, H Korkmaz, Y Ergun, O Erel. Thiol/disulfide homeostasis in postmenopausal osteoporosis. Journal of endocrinological investigation. 2017 Apr;40(4):431-435