Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells.

Interleukin-3 (IL-3) is a well-characterized growth factor in hematopoietic cells, but it is also expressed in other cell types with poorly described functions. Many studies have provided evidence that IL-3 plays an important role in cell survival. We have previously shown that IL-3 is able to increase glucose uptake in HEK293 cells, suggesting that this factor requires sustained glucose metabolism to promote cell survival. In this study, we demonstrate that IL-3 contributes to cell survival under oxidative stress, a prominent feature in the pathophysiology of cancer, diabetes, and neurodegenerative diseases, as well as in the aging process. Our results suggest a molecular mechanism that involves signaling pathways mediated by PI-3k/Akt and Erk. Altogether, these findings show an important role for IL-3 in supporting the viability of non-hematopoietic systems. J. Cell. Biochem. 118: 1330-1340, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Citation

Camila López, Patricia Zamorano, Stefanie Teuber, Mónica Salas, Carola Otth, María A Hidalgo, Ilona Concha, Angara Zambrano. Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells. Journal of cellular biochemistry. 2017 Jun;118(6):1330-1340

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PMID: 27862234

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