Telavancin Is Active against Experimental Aortic Valve Endocarditis Caused by Daptomycin- and Methicillin-Resistant Staphylococcus aureus Strains.

Wessam Abdelhady, Arnold S Bayer, Rachelle Gonzales, Liang Li, Yan Q Xiong

Antimicrobial agents and chemotherapy 2017 Feb

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We compared the efficacy of telavancin (TLV) and daptomycin (DAP) in an experimental rabbit endocarditis model caused by two clinically derived daptomycin-resistant (DAPr) methicillin-resistant Staphylococcus aureus (MRSA) strains. TLV treatment significantly reduced MRSA densities in all target tissues and increased the percentage of these organs rendered culture negative compared to those with the untreated control or DAP-treated animals. These results demonstrate that TLV has potent in vivo efficacy against DAPr MRSA isolates in this invasive endovascular infection model. Copyright © 2017 American Society for Microbiology.

Citation

Wessam Abdelhady, Arnold S Bayer, Rachelle Gonzales, Liang Li, Yan Q Xiong. Telavancin Is Active against Experimental Aortic Valve Endocarditis Caused by Daptomycin- and Methicillin-Resistant Staphylococcus aureus Strains. Antimicrobial agents and chemotherapy. 2017 Feb;61(2)