Isothermic and kinetic studies of uremic metabolite adsorption with Ambersorb XE-344 resin.

Ambersorb XE-344 resin is specific for certain metabolites because of unique pore size distribution and surface chemistry. Affinities are greatest for molecules which are significantly aromatic or nonpolar. For clinical purposes, however, the capacity for and kinetics of adsorbing certain aliphatic nitrogenous metabolites (e.g., guanidine) may enhance dialysis treatment as well. While significant affinity for peak 7c has been demonstrated, the resin does not adsorb the steroid, glycoprotein, or polypeptide molecules thus far tested. Despite the carbonaceous nature of Ambersorb XE-344, it does not adsorb the inorganic electrolytes.

Citation

J D Bobeck, J J Cipoletti, M Wexler. Isothermic and kinetic studies of uremic metabolite adsorption with Ambersorb XE-344 resin. Kidney international. Supplement. 1978 Jun(8):S163-9

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PMID: 278885

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