SPOCK1 is up-regulated and promotes tumor growth via the PI3K/AKT signaling pathway in colorectal cancer.

Jiaxuan Zhang, Xiaofei Zhi, Shiyu Shi, Ran Tao, Peisheng Chen, Shiyu Sun, Longjun Bian, Zhangyan Xu, Lilin Ma

Biochemical and biophysical research communications 2017 Jan 22

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SPOCK1 encodes a Ca2+-binding matricellular glycoprotein which plays an oncogenic role in cancer cells. However, the role of SPOCK1 in the pathogenesis of colorectal cancer (CRC) has not been determined. Here, SPOCK1 was found higher expressed in CRC tissues than that of adjacent normal tissues. Furthermore, up-regulated expression of SPOCK1 in CRC patients was associated with tumor size and TNM stage. In addition, we observed that the depletion of SPOCK1 inhibited proliferation in vitro and tumorigenicity in vivo and promoted apoptosis in cell culture. Our data suggest that inactivation of PI3K/Akt signaling pathway was involved in down-regulation of SPOCK1-mediated suppression of tumor cell proliferation. These results suggest that SPOCK1 expression is correlated with malignant features of CRC and may serve as potential therapeutic and preventive strategies for CRC. Copyright © 2016 Elsevier Inc. All rights reserved.

Citation

Jiaxuan Zhang, Xiaofei Zhi, Shiyu Shi, Ran Tao, Peisheng Chen, Shiyu Sun, Longjun Bian, Zhangyan Xu, Lilin Ma. SPOCK1 is up-regulated and promotes tumor growth via the PI3K/AKT signaling pathway in colorectal cancer. Biochemical and biophysical research communications. 2017 Jan 22;482(4):870-876