Exploring the activity of a polyazine bridged Ru(ii)-Pt(ii) supramolecule in F98 rat malignant glioma cells.

Jie Zhu, José Á Rodríguez-Corrales, Reece Prussin, Zongmin Zhao, Anthony Dominijanni, Samantha L Hopkins, Brenda S J Winkel, John L Robertson, Karen J Brewer

Chemical communications (Cambridge, England) 2016 Dec 20

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The mixed-metal supramolecular complex, [(Ph2phen)2Ru(dpp)PtCl2]2+, displays significant DNA modification, cell growth inhibition, and toxicity towards F98 malignant glioma cells following visible light irradiation. The design of this complex affords superior cellular uptake and antiproliferative activity compared to the classic chemotherapeutic agent, cisplatin.

Citation

Jie Zhu, José Á Rodríguez-Corrales, Reece Prussin, Zongmin Zhao, Anthony Dominijanni, Samantha L Hopkins, Brenda S J Winkel, John L Robertson, Karen J Brewer. Exploring the activity of a polyazine bridged Ru(ii)-Pt(ii) supramolecule in F98 rat malignant glioma cells. Chemical communications (Cambridge, England). 2016 Dec 20;53(1):145-148