Cellular responses to replication stress: Implications in cancer biology and therapy.

Hui-Ju Hsieh, Guang Peng

DNA repair 2017 Jan

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DNA replication is essential for cell proliferation. Any obstacles during replication cause replication stress, which may lead to genomic instability and cancer formation. In this review, we summarize the physiological DNA replication process and the normal cellular response to replication stress. We also outline specialized therapies in clinical trials based on current knowledge and future perspectives in the field. Copyright © 2016 Elsevier B.V. All rights reserved.