Sangmi Oh, Sunghee Yoon, Esther Youn, Ichiro Kawasaki, Yhong-Hee Shim
Biochemical and biophysical research communications 2017 Jan 22Cell division cycle 25 (Cdc25) is an evolutionarily conserved phosphatase that promotes cell cycle progression by activating cyclin-dependent kinases (Cdks) which are inactivated by Wee1/Myt1 kinases. It was previously reported that cdc-25.2 promotes oocyte maturation and intestinal cell divisions in Caenorhabditis elegans hermaphrodites. Here, we report a novel function of cdc-25.2 in male tail development which was significantly deformed by cdc-25.2 RNAi depletion and in cdc-25.2 mutant males. The deformation was also observed after RNAi depletion of other cell cycle regulators, cdk-1, cyb-3, cyd-1, and cyl-1. Furthermore, wee-1.3 counteracted cdc-25.2 in male tail development as observed in oocyte maturation and intestine development. The number of cells in ray precursor cell lineages was significantly reduced in cdc-25.2 depleted males. These results indicate that CDC-25.2 is essential for cell divisions in ray precursor cell lineages for proper male tail development. Copyright © 2016 Elsevier Inc. All rights reserved.
Sangmi Oh, Sunghee Yoon, Esther Youn, Ichiro Kawasaki, Yhong-Hee Shim. cdc-25.2, a Caenorhabditis elegans ortholog of cdc25, is required for male tail morphogenesis. Biochemical and biophysical research communications. 2017 Jan 22;482(4):1213-1218
PMID: 27923661
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