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Performance of a MALDI-TOF MS-based imipenem hydrolysis assay incorporating zinc sulfate.
Diagnostic microbiology and infectious disease 2017 MarSizes of these terms reflect their relevance to your search.
A MALDI-TOF MS1-based imipenem hydrolysis assay was modified by adding ZnSO4. This improved detection of metallo-β-lactamase producing strains without compromising detection of other carbapenemase types. Using 129 genetically characterized Gram-negative bacilli, the sensitivity and specificity were 98.5% (95% confidence interval [CI]: 91.9-99.7%) and 100% (95% CI: 94.3-100%), respectively. Copyright © 2016 Elsevier Inc. All rights reserved.
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James Knox, Enzo Palombo. Performance of a MALDI-TOF MS-based imipenem hydrolysis assay incorporating zinc sulfate. Diagnostic microbiology and infectious disease. 2017 Mar;87(3):258-260
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PMID: 27939285
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