The efficacy of prazosin for the treatment of posttraumatic stress disorder nightmares in U.S. military veterans.

Annamarie Breen, Kory Blankley, Julie Fine

Journal of the American Association of Nurse Practitioners 2017 Feb

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Nightmares associated with posttraumatic stress disorder (PTSD) are a hallmark symptom among U.S. military veterans who have seen combat. Management of combat-related nightmares can be difficult and current pharmacologic options are limited and tend to have adverse side effects. The aim of this review is to explore recent literature regarding the efficacy of prazosin for the treatment of nightmare disorder in the veteran population. Recent literature consisting of three systematic reviews was reviewed, as well as current clinical guidelines published by The Department of Veterans Affairs (VA) and The Department of Defense (DoD) and the American Academy of Sleep Medicine (AASM). Prazosin has been shown to be effective in the treatment of PTSD trauma-related nightmares. As a result of its low side effect profile and abilities to improve both sleep and reduce trauma nightmares, prazosin has been recommended as an adjunct therapy. Prazosin should be initiated as an adjunctive treatment to promote sleep in those suffering from PTSD nightmares. It should be initiated at 1 mg and then titrated upward until absence or desired reduction of nightmares is achieved, with a maximum dosage recommendation of 20 mg at bedtime and 5 mg midmorning. ©2016 American Association of Nurse Practitioners.

Citation

Annamarie Breen, Kory Blankley, Julie Fine. The efficacy of prazosin for the treatment of posttraumatic stress disorder nightmares in U.S. military veterans. Journal of the American Association of Nurse Practitioners. 2017 Feb;29(2):65-69