Fumarates and Cancer.

Gwenny M Fuhler, Hester Eppinga, Maikel P Peppelenbosch

Trends in molecular medicine 2017 Jan

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Accumulation of intermediate metabolites of the tricarboxylic acid (TCA) cycle in tumor cells can cause epithelial-to-mesenchymal transition (EMT), although the exact mechanisms remain elusive. Recent studies show that the oncometabolite fumarate, which accumulates in fumarate hydratase-deficient renal cancers, confers tumor aggressiveness by causing epigenetic changes in the antimetastatic miRNA cluster mir-200ba429. This may have important implications for the use of fumarates in the clinic. Copyright © 2016 Elsevier Ltd. All rights reserved.