N-RAS expression in patients with salivary adenoid cystic carcinoma: association with clinicopathologic features and prognosis.

Jiuling Yue, Xiaonan Liu, Shanshan Zhuo, Wenchao Zhang

Oral surgery, oral medicine, oral pathology and oral radiology 2017 Feb

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The aim of this study was to investigate N-RAS expression in patients with salivary adenoid cystic carcinoma (SACC) and to analyze its association with clinicopathologic features and prognosis. We determined N-RAS expression in SACC tumors via immunohistochemistry and evaluated the association between N-RAS expression and clinicopathologic variables. The disease-free survival (DFS) curves were plotted by using the Kaplan-Meier method. The parameters of prognostic significance found by univariate analysis were tested by a multivariate Cox regression model. N-RAS expression was detected in 61 of 72 SACC tumor samples (84.7%). In univariate analyses, N-RAS expression was associated with clinical stage, tumor size, adjacent tissue invasion, and distant metastasis. N-RAS expression was associated with DFS in univariate analysis; however, in multivariate analysis, N-RAS was not an independent prognostic indicator, but clinical stage (0.04) and histologic subtype (0.02) were statistically significant. Our data suggest that N-RAS was overexpressed in SACC tissues, but was not an independent prognostic indicator of DFS. Only clinical stage and histologic subtype were prognostic indicators of DFS. Copyright © 2016 Elsevier Inc. All rights reserved.

Citation

Jiuling Yue, Xiaonan Liu, Shanshan Zhuo, Wenchao Zhang. N-RAS expression in patients with salivary adenoid cystic carcinoma: association with clinicopathologic features and prognosis. Oral surgery, oral medicine, oral pathology and oral radiology. 2017 Feb;123(2):242-248