Correlation Engine 2.0
Clear Search sequence regions

  • brain (1)
  • cells (3)
  • cilia (8)
  • cilium (1)
  • factors (1)
  • fallopian tubes (1)
  • humans (1)
  • ion channel (6)
  • signal (1)
  • Sizes of these terms reflect their relevance to your search.

    Mammalian cilia are ubiquitous appendages found on the apical surface of cells. Primary and motile cilia are distinct in both morphology and function. Most cells have a solitary primary cilium (9+0), which lacks the central microtubule doublet characteristic of motile cilia (9+2). The immotile primary cilia house unique signaling components and sequester several important transcription factors. In contrast, motile cilia commonly extend into the lumen of respiratory airways, fallopian tubes, and brain ventricles to move their contents and/or produce gradients. In this review, we focus on the composition of putative ion channels found in both types of cilia and in the periciliary membrane and discuss their proposed functions. Our discussion does not cover specialized cilia in photoreceptor or olfactory cells, which express many more ion channels. © 2017 Pablo et al.


    Juan Lorenzo Pablo, Paul G DeCaen, David E Clapham. Progress in ciliary ion channel physiology. The Journal of general physiology. 2017 Jan;149(1):37-47

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 27999145

    View Full Text