Selected flavonoid compounds as promising inhibitors of protein kinase CK2α and CK2α', the catalytic subunits of CK2.

Andrea Baier, Anna Galicka, Jolanta Nazaruk, Ryszard Szyszka

Phytochemistry 2017 Apr

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CK2 is a ubiquitous protein kinase involved in many cell functions. During the last years it became an interesting target in cancer research. A series of flavonoid compounds was tested as inhibitors of protein kinase CK2. Several substances were found to be highly active against both catalytic subunits with IC50 values below 1 μM in case of CK2α'. The most promising inhibitor we identified is chrysoeriol with IC50 values of 250 and 34 nM for CK2α and CK2α', respectively. Copyright © 2016 Elsevier Ltd. All rights reserved.

Citation

Andrea Baier, Anna Galicka, Jolanta Nazaruk, Ryszard Szyszka. Selected flavonoid compounds as promising inhibitors of protein kinase CK2α and CK2α', the catalytic subunits of CK2. Phytochemistry. 2017 Apr;136:39-45