Exploring Polyubiquitin as a Flexible Multiple-Ligand Binding Platform.

Linear (head-to-tail linked) polyubiquitin chains play a key role in the regulation of NF-κB signaling. In this issue of Structure, Lin et al. (2017) shed light on how linear tri-ubiquitin binds to ABIN2, a molecule that shares ubiquitin-binding properties of NEMO, the key activator of NF-κB. Copyright © 2016 Elsevier Ltd. All rights reserved.

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David Fushman. Exploring Polyubiquitin as a Flexible Multiple-Ligand Binding Platform. Structure (London, England : 1993). 2017 Jan 03;25(1):1-3

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PMID: 28052234

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