Yi Dong, Suhua Wang, Chunting Wang, Zihua Li, Yao Ma, Gang Liu
Journal of medicinal chemistry 2017 Feb 09A noncleavable paclitaxel (PTX) and N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) derivative conjugate, 22 (DY-16-43), and its analogues were prepared and characterized as antagonists of NOD2 signaling. This conjugate enhanced the antitumor and antimetastatic efficacy of PTX in Lewis lung carcinoma (LLC) tumor-bearing mice. This work first describes a molecular strategy that enables the sensitization of a chemotherapeutic response via antagonizing NOD2 inflammatory signaling and suggests NOD2 antagonist as potential adjunct in treating non-small-cell lung cancer (NSCLC).
Yi Dong, Suhua Wang, Chunting Wang, Zihua Li, Yao Ma, Gang Liu. Antagonizing NOD2 Signaling with Conjugates of Paclitaxel and Muramyl Dipeptide Derivatives Sensitizes Paclitaxel Therapy and Significantly Prevents Tumor Metastasis. Journal of medicinal chemistry. 2017 Feb 09;60(3):1219-1224
PMID: 28075581
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