Correlation Engine 2.0
Clear Search sequence regions

  • casein (3)
  • cell (2)
  • humans (1)
  • phosphates (2)
  • phosphoproteins (4)
  • phosphorus (2)
  • Phosvitin (2)
  • Sizes of these terms reflect their relevance to your search.

    The first phosphoprotein (casein) was discovered in 1883, yet the enzyme responsible for its phosphorylation was identified only 130 years later, in 2012. In the intervening time, especially in the last decades of the 1900s, it became evident that, far from being an oddity, phosphorylation affects the majority of eukaryotic proteins during their lifespan, and that this reaction is catalysed by the members of a large family of protein kinases, susceptible to a variety of stimuli controlling nearly every aspect of life and death. The aim of this review is to present a historical account of the main steps of this spectacular revolution, which transformed our conception of a biochemical reaction originally held as a sporadic curiosity into the master mechanism governing cell regulation, and, if it is perturbed, causing cell dysregulation. © 2017 Federation of European Biochemical Societies.


    Andrea Venerando, Luca Cesaro, Lorenzo A Pinna. From phosphoproteins to phosphoproteomes: a historical account. The FEBS journal. 2017 Jul;284(13):1936-1951

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 28079298

    View Full Text