99mTc ethoxy methylpropyl isonitrile: a radioactive tracer for myocardial perfusion imaging.

A van Aswegen, A J van Wyk, C P Herbst, A C Otto, A Viviers, J Koekemoer, O Knoesen, M G Lötter, P C Minnaar, P H Kleynhans

Medical Faculty, University of the Orange Free State, Bloemfontein, South Africa.

International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989

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The initial experience with a new 99mTc labelled myocardial perfusion agent, ethoxy methylpropyl isonitrile (EMI), is described in the primate as model. Rapid biliary clearance of EMI ensures low radionuclide concentration in the liver and lungs after 60 min. Adequate visualization of the myocardium is therefore possible. Heart-to-lung and heart-to-liver ratios of 1.52 and 2.45 respectively were obtained. EMI is an efficient imaging agent to evaluate myocardial ischemia and infarction.

Citation

A van Aswegen, A J van Wyk, C P Herbst, A C Otto, A Viviers, J Koekemoer, O Knoesen, M G Lötter, P C Minnaar, P H Kleynhans. 99mTc ethoxy methylpropyl isonitrile: a radioactive tracer for myocardial perfusion imaging. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 1989;16(5):455-9