Herpes simplex encephalitis (HSE) can be complicated by adverse events in the acute phase. We herein present the case of a 71-year-old woman with HSE complicated by cerebral hemorrhage. She presented with acute deterioration of consciousness and fever and was diagnosed with HSE based on the detection of herpes simplex virus-1 in the cerebrospinal fluid by a polymerase chain reaction. The cerebral hemorrhage developed during acyclovir therapy; however, its diagnosis was delayed for 2 days. After the conservative treatment of the cerebral hemorrhage, the patient made a near-complete recovery. Cerebral hemorrhage should be considered as an acute-phase complication of HSE.
Yukinori Harada, Yuuta Hara. Herpes Simplex Encephalitis Complicated by Cerebral Hemorrhage during Acyclovir Therapy. Internal medicine (Tokyo, Japan). 2017;56(2):225-229
PMID: 28090058
View Full Text