Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin.

Fangfang Xu, Qiuxia Yang, Lilan Wu, Rui Qi, Yunshan Wu, Yucui Li, Lipeng Tang, De-An Guo, Bo Liu

PloS one 2017

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The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.

Citation

Fangfang Xu, Qiuxia Yang, Lilan Wu, Rui Qi, Yunshan Wu, Yucui Li, Lipeng Tang, De-An Guo, Bo Liu. Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin. PloS one. 2017;12(1):e0169578