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To evaluate the levels of peripheral blood CD34+ cells in women who subsequently had a spontaneous miscarriage (SM). We enrolled 11 women who had SM, matching them for age, BMI and gestational age with 33 healthy pregnancies (controls). From a blood sample at 9th-11th weeks of pregnancy, we evaluated PAPP-A, free β-hCG, T (suppressor and helper), NK, B, CD34+ cells. In peripheral blood of women who had SM, PAPP-A and CD34+ cells were significantly lower (p < 0.001) compared to control group. CD34+ cell low level in peripheral blood is associated with increased risk of SM.


Domenico Giordano, Saverio Loddo, Antonio Simone Laganà, Giuseppe Coppolino, Giuseppe Zoccali, Antonino Di Benedetto, Angelo Santamaria, Michele Buemi, Rosario D'Anna. Peripheral blood CD34+ cells as a novel and noninvasive early marker of first trimester miscarriage: results from a case-control analysis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2018 Jan;31(2):258-260

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PMID: 28110587

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