GPER Promoter Methylation Controls GPER Expression in Breast Cancer Patients.

Recently, we found that G-protein-coupled estrogen receptor (GPER) protein expression decreased during breast carcinogenesis, and that GPER promoter is methylated. Here we analyzed GPER promoter methylation in 260 primary breast cancer specimens by methylation-specific polymerized chain reaction. The results demonstrated that GPER protein down-regulation significantly correlated with GPER promoter hypermethylation (p < .001). Comparison of 108 tumors and matched normal breast tissues indicated a significant GPER down-regulation in cancer tissues correlating with GPER promoter hypermethylation (p < .001). The latter was an unfavorable factor for overall survival of patients with triple-negative breast cancer (p = .025). Thus GPER promoter hypermethylation might be used as a prognostic factor.

Citation

Christine Weissenborn, Tanja Ignatov, Norbert Nass, Thomas Kalinski, Serban Dan Costa, Ana Claudia Zenclussen, Atanas Ignatov. GPER Promoter Methylation Controls GPER Expression in Breast Cancer Patients. Cancer investigation. 2017 Feb 07;35(2):100-107

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PMID: 28118074

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