Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

How differential levels of gene expression are controlled in post-mitotic neurons is poorly understood. In the Drosophila retina, expression of the transcription factor Defective Proventriculus (Dve) at distinct cell type-specific levels is required for terminal differentiation of color- and motion-detecting photoreceptors. Here, we find that the activities of two cis-regulatory enhancers are coordinated to drive dve expression in the fly eye. Three transcription factors act on these enhancers to determine cell-type specificity. Negative autoregulation by Dve maintains expression from each enhancer at distinct homeostatic levels. One enhancer acts as an inducible backup ('dark' shadow enhancer) that is normally repressed but becomes active in the absence of the other enhancer. Thus, two enhancers integrate combinatorial transcription factor input, feedback and redundancy to generate cell type-specific levels of dve expression and stable photoreceptor fate. This regulatory logic may represent a general paradigm for how precise levels of gene expression are established and maintained in post-mitotic neurons. © 2017. Published by The Company of Biologists Ltd.


Jenny Yan, Caitlin Anderson, Kayla Viets, Sang Tran, Gregory Goldberg, Stephen Small, Robert J Johnston. Regulatory logic driving stable levels of defective proventriculus expression during terminal photoreceptor specification in flies. Development (Cambridge, England). 2017 Mar 01;144(5):844-855

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 28126841

View Full Text