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SWI/SNF complex in cancer.
Chao Lu, C David Allis
Nature genetics 2017 Jan 31
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Four studies in this issue report new mechanisms underlying the function of the chromatin remodeling SWI/SNF complex in controlling gene expression and suppressing tumor development, providing valuable insights into the treatment of cancers harboring mutations in genes encoding SWI/SNF complex subunits.
Citation
Chao Lu, C David Allis.
SWI/SNF complex in cancer.
Nature genetics.
2017 Jan 31;49(2):178-179
Mesh Tags
Animals
Chromatin
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Gene Expression Regulation, Neoplastic
Histone-Lysine N-Methyltransferase
Humans
Mice
Neoplasms
Nuclear Proteins
Polycomb-Group Proteins
SMARCB1 Protein
Transcription Factors
Substances
Arid1a protein, mouse
Arid1b protein, mouse
Chromatin
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Drosophila Proteins
Nuclear Proteins
PRC1 protein, Drosophila
Polycomb-Group Proteins
SMARCB1 Protein
SMARCB1 protein, human
SWI-SNF-B chromatin-remodeling complex
Transcription Factors
Histone-Lysine N-Methyltransferase
PRC2 protein, Drosophila
PMID: 28138149
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