BNCT of skin tumors using the high-energy D-T neutrons.

Owing to the continuing need for providing improved and universally accepted facilities to be used in radiation therapies, a number of recently published BNCT-related studies have focused on investigating appropriate neutron sources as alternatives for nuclear reactors. Of special interest are D-T neutron generators, which theoretically have shown the potential to be utilized as neutron sources for BNCT of deep-seated tumors. This work is devoted to investigate the feasibility of using the high-energy neutrons emitted from these generators for treatment of surface tumors, especially skin. Using a set of MCNPX simulations, the D-T neutrons are passed through an optimized arrangement of materials to slow-down toward the desired energy range, and to remove the neutron and gamma contamination considering the IAEA recommended criteria, especially determined for pre-clinical survey for treatment of surface tumors. By assessment with these parameters, it is shown that the designed beam, corresponding to a configuration composed of natural uranium as neutron multiplier, D2O as moderator, Pb as reflector, Bi as gamma filter, and polyethylene and BeO as collimators provides high-intensity of desired neutrons, and low-background doses as well. It was found that an appropriate material for collimator, if accompanied with an optimized geometry, is an important parameter for keeping the undesired components to the recommended level. A typical simulated phantom, subjected to the irradiation of the designed spectrum, is used to study the performance of the resultant beam in shallow tissue. For an arbitrary chosen 10B concentration, the evaluated depth-dose curves show that the proposed configuration establishes acceptable agreement between the appropriate neutron intensity and penetration to desired depth in tissue in a reasonable treatment time of about 25-38min. Considering the simulations carried out, the total dose delivered to the tumor is expected to be of about 4.2 times higher than that delivered to the first depths in healthy tissue, and of about 2.4 times higher than that delivered to the normal skin. These results in essence endorse the ability of D-T neutron generators to be used for BNCT of surface tumors, even with the yield of ∼1012n/s. Copyright © 2017 Elsevier Ltd. All rights reserved.

Citation

S Farhad Masoudi, Fatemeh S Rasouli, Marjan Ghasemi. BNCT of skin tumors using the high-energy D-T neutrons. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2017 Apr;122:158-163

PMID: 28161648

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