CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice.

Ying Feng, Jun Cheng, Baozhu Wei, Yanggan Wang

Oncotarget 2017 Mar 14

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The Ca/calmodulin-dependent protein kinase II (CaMKII), an arrhythmogenic molecule, is excessively activated in cardiac hypertrophy. Here, we investigated the effect of CaMKII inhibition in isoproterenol (ISO)-induced arrhythmias in hypertrophic mice. ISO induced multiple types of arrhythmias in the hypertrophic mice but not in the normal mice. The QTc intervals were prolonged and the amplitudes of T waves were increased significantly by ISO prior to arrhythmia initiation. Inhibition of CaMKII prevented ISO-induced QTc prolongation and T wave elevation and abrogated arrhythmia induction. Pressure-overload cardiac hypertrophy was induced in mice by thoracic aortic banding. Arrhythmias were recorded by electrocardiogram in conscious mice. CaMKII inhibition is effective in suppressing adrenergic activation-induced ventricular arrhythmias in cardiac hypertrophy, of which the ventricular ischemia-induced CaMKII activation plays an important role.

Citation

Ying Feng, Jun Cheng, Baozhu Wei, Yanggan Wang. CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice. Oncotarget. 2017 Mar 14;8(11):17504-17509