WNK Kinase Signaling in Ion Homeostasis and Human Disease.

Masoud Shekarabi, Jinwei Zhang, Arjun R Khanna, David H Ellison, Eric Delpire, Kristopher T Kahle

Cell metabolism 2017 Feb 07

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WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation. Copyright © 2017 Elsevier Inc. All rights reserved.

Citation

Masoud Shekarabi, Jinwei Zhang, Arjun R Khanna, David H Ellison, Eric Delpire, Kristopher T Kahle. WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell metabolism. 2017 Feb 07;25(2):285-299