Recruitment of PP1 to the centrosomal scaffold protein CEP192.

Isha Nasa, Laura Trinkle-Mulcahy, P Douglas, Sibapriya Chaudhuri, S P Lees-Miller, Kyung S Lee, Greg B Moorhead

Biochemical and biophysical research communications 2017 Mar 18

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Centrosomal protein of 192 kDa (CEP192) is a scaffolding protein that recruits the mitotic protein kinases Aurora A and PLK1 to the centrosome. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif. The threonine of the KHVTF motif is phosphorylated during mitosis and protein kinase inhibition studies suggest this to be a PLK1-dependent process. Copyright © 2017 Elsevier Inc. All rights reserved.

Citation

Isha Nasa, Laura Trinkle-Mulcahy, P Douglas, Sibapriya Chaudhuri, S P Lees-Miller, Kyung S Lee, Greg B Moorhead. Recruitment of PP1 to the centrosomal scaffold protein CEP192. Biochemical and biophysical research communications. 2017 Mar 18;484(4):864-870