Folate nutrition and blood-brain barrier dysfunction.

Patrick J Stover, Jane Durga, Martha S Field

Current opinion in biotechnology 2017 Apr

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Mammals require essential nutrients from dietary sources to support normal metabolic, physiological and neuronal functions, to prevent diseases of nutritional deficiency as well as to prevent chronic disease. Disease and/or its treatment can modify fundamental biological processes including cellular nutrient accretion, stability and function in cells. These effects can be isolated to a specific diseased organ in the absence of whole-body alterations in nutrient status or biochemistry. Loss of blood-brain barrier function, which occurs in in-born errors of metabolism and in chronic disease, can cause brain-specific folate deficiency and contribute to disease co-morbidity. The role of brain folate deficiency in neuropsychiatric disorders is reviewed, as well as emerging diagnostic and nutritional strategies to identify and address brain folate deficiency in blood-brain barrier dysfunction. Copyright © 2017 Elsevier Ltd. All rights reserved.

Citation

Patrick J Stover, Jane Durga, Martha S Field. Folate nutrition and blood-brain barrier dysfunction. Current opinion in biotechnology. 2017 Apr;44:146-152