Silver nanoparticles alter the permeability of sheep pleura and of sheep and human pleural mesothelial cell monolayers.

Zoi V Arsenopoulou, Ioannis A Taitzoglou, Paschalis-Adam Molyvdas, Konstantinos I Gourgoulianis, Chrissi Hatzoglou, Sotirios G Zarogiannis

Environmental toxicology and pharmacology 2017 Mar

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Nanoparticles have been implicated in the development of pleural effusions in exposed factory workers while in experimental animal studies it has been shown that they induce inflammation, fibrosis and carcinogenesis in the pleura. The scope of this study was to investigate the direct effects of silver nanoparticles exposure on the membrane permeability of sheep parietal pleura, of primary sheep pleural cell monolayers and on a human mesothelial cell line. Our findings suggest that acute (30min) exposure increases the pleural permeability ex vivo, while longer (24h) exposure in vivo leads to late decrease of the pleural cell monolayers permeability. Copyright © 2017 Elsevier B.V. All rights reserved.

Citation

Zoi V Arsenopoulou, Ioannis A Taitzoglou, Paschalis-Adam Molyvdas, Konstantinos I Gourgoulianis, Chrissi Hatzoglou, Sotirios G Zarogiannis. Silver nanoparticles alter the permeability of sheep pleura and of sheep and human pleural mesothelial cell monolayers. Environmental toxicology and pharmacology. 2017 Mar;50:212-215