Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study.

Adipose tissue is an important endocrine organ that secretes a number of adipokines, such as adiponectin (ADIPOQ), leptin (LEP), leptin receptor (LEPR), and resistin (RETN) which may be implicated in obesity. Some adipokines' polymorphisms of genes might influence their concentrations and/or activities. Our aim was to study the relationship between seven SNPs in ADIPOQ (+45Trs2241766); +276Grs1501299); -4255Crs822393); -395Grs17366568)), LEP (2548Grs7799039)), LEPR (223Qrs1137101)), and RETN (-420Crs1862513)) and obesity in Hammam Sousse Sahloul Heart Study (HSHS). The study, carried out between February and June 2009, is mainly focused on 1121 respondents in HSHS which is a population-based epidemiological study of type "community-based" on cardiovascular risk. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum lipids and anthropometric parameters were measured. Statistic analysis was performed on SPSSv19. The polymorphisms of ADIPOQ 4522CLEP 2548GRETN 420Codds ratios (ORs) of obesity associated with mutated genotypes of each polymorphism were respectively OR=1.38, P=.037; OR=0.608, P<.001; OR=2.23, P=.034; and OR=2.18, P<.001. The 276GLEP 2548Gwaist circumference and hip measurements. ADIPOQ, LEP, and RETN gene polymorphisms were associated with obesity parameters in HSHS population. © 2017 Wiley Periodicals, Inc.

Citation

Nesrine Zayani, Asma Omezzine, Imen Boumaiza, Ons Achour, Lamia Rebhi, Jihen Rejeb, Nabila Ben Rejeb, Ahmed Ben Abdelaziz, Ali Bouslama. Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study. Journal of clinical laboratory analysis. 2017 Nov;31(6)

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PMID: 28195351

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