Extracellular regulation of BMP signaling: welcome to the matrix.

Georg Sedlmeier, Jonathan P Sleeman

Biochemical Society transactions 2017 Feb 08

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Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.

Citation

Georg Sedlmeier, Jonathan P Sleeman. Extracellular regulation of BMP signaling: welcome to the matrix. Biochemical Society transactions. 2017 Feb 08;45(1):173-181