Matteo Megna, Serena Lembo, Nicola Balato, Giuseppe Monfrecola
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 2017 JunUltraviolet (UV) radiation exerts different harmful effects on human health, being the main etiological agent of certain skin cancers and photoaging. In this context, photoprotection, intended as a set of measures adopted to limit and prevent the effects of UV radiation, plays a critical role in avoiding undesired sunlight outcomes. Traditional sunscreens represent a widely used photoprotective approach, even if they exert a "passive photoprotection" and are not effective once damage to skin cells has been generated after sun exposure. Conversely, "active" photoprotection is represented by topical sunscreens including also antioxidants and liposome-containing DNA repair enzymes, which may constitute a photostrategy filling the current gap in sun protection. In the current review, we focused on "active" photoprotection at a topical level, reporting present knowledge and future prospective regarding DNA repair enzymes such as photolyase, endonuclease and 8-oxoguanine glycosylase which are able to enhance the protective power of traditional sunscreens.
Matteo Megna, Serena Lembo, Nicola Balato, Giuseppe Monfrecola. Active" photoprotection: sunscreens with DNA repair enzymes. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia. 2017 Jun;152(3):302-307
PMID: 28209050
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