MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth.

Chuangjian Wang, Xiaobo Zhang, Chunlin Zhang, Fuying Zhai, Ying Li, Zongqiang Huang

Pathology, research and practice 2017 Apr

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Osteosarcoma is the most common type of bone cancer prevalent in young adults. Recent studies suggested that aberrant microRNA expression plays an essential role in osteosarcoma pathogenesis. In this study, we found miR-155 up-regulation in different osteosarcoma cell lines U2OS, Saos-2 and MG-63. Through bioinformatic prediction and analysis, we identified its target MAP3K10 that involved in cell proliferation and apoptosis. This work demonstrates novel interaction between microRNA, intercellular MAPK signaling and apoptosis in osteosarcoma, which will provide targets for therapeutic development. Copyright © 2017 Elsevier GmbH. All rights reserved.

Citation

Chuangjian Wang, Xiaobo Zhang, Chunlin Zhang, Fuying Zhai, Ying Li, Zongqiang Huang. MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth. Pathology, research and practice. 2017 Apr;213(4):389-393