Targeting IKK and NF-κB for Therapy.

J K Durand, A S Baldwin

Advances in protein chemistry and structural biology 2017

filter terms:

In addition to regulating immune responses, the NF-κB family of transcription factors also promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have become appealing therapeutic targets because of their critical roles in the progression of many diseases including chronic inflammation and cancer. Here, we discuss the conditions that lead to pathway activation, the effects of constitutive activation, and some of the strategies used to inhibit NF-κB signaling. © 2017 Elsevier Inc. All rights reserved.