Cardio-oncology Related to Heart Failure: Epidermal Growth Factor Receptor Target-Based Therapy.

Benjamin Kenigsberg, Varun Jain, Ana Barac

Heart failure clinics 2017 Apr

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Cancer therapy targeting the epidermal growth factor receptor (EGFR)/erythroblastic leukemia viral oncogene B (ErbB)/human EGFR receptor (HER) family of tyrosine kinases has been successfully used in treatment of several malignancies. The ErbB pathways play a role in the maintenance of cardiac homeostasis. This article summarizes current knowledge about EGFR/ErbB/HER receptor-targeted cancer therapeutics focusing on their cardiotoxicity profiles, molecular mechanisms, and implications in clinical cardio-oncology. The article discusses challenges in predicting, monitoring, and treating cardiac dysfunction and heart failure associated with ErbB-targeted cancer therapeutics and highlights opportunities for researchers and clinical investigators. Copyright © 2016 Elsevier Inc. All rights reserved.

Citation

Benjamin Kenigsberg, Varun Jain, Ana Barac. Cardio-oncology Related to Heart Failure: Epidermal Growth Factor Receptor Target-Based Therapy. Heart failure clinics. 2017 Apr;13(2):297-309