SUMO conjugation - a mechanistic view.

Andrea Pichler, Chronis Fatouros, Heekyoung Lee, Nathalie Eisenhardt

Biomolecular concepts 2017 Mar 01

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The regulation of protein fate by modification with the small ubiquitin-related modifier (SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly dynamic due to the opposing activities of SUMO conjugation and SUMO deconjugation. SUMO conjugation is performed by the hierarchical action of E1, E2 and E3 enzymes, while its deconjugation involves SUMO-specific proteases. In this review, we summarize and compare the mechanistic principles of how SUMO gets conjugated to its substrate. We focus on the interplay of the E1, E2 and E3 enzymes and discuss how specificity could be achieved given the limited number of conjugating enzymes and the thousands of substrates.

Citation

Andrea Pichler, Chronis Fatouros, Heekyoung Lee, Nathalie Eisenhardt. SUMO conjugation - a mechanistic view. Biomolecular concepts. 2017 Mar 01;8(1):13-36