Insights into CCL21's roles in immunosurveillance and immunotherapy for gliomas.

Thien Nguyen, Carlito Lagman, Lawrance K Chung, Cheng Hao Jacky Chen, Jessica Poon, Vera Ong, Brittany L Voth, Isaac Yang

Journal of neuroimmunology 2017 Apr 15

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Chemokine (C-C) motif ligand 21 (CCL21) is involved in immunosurveillance and has recently garnered the attention of neuro-oncologists and neuroscientists. CCL21 contains an extended C-terminus, which increases binding to lymphatic glycosaminoglycans and provides a mechanism for cell trafficking by forming a stationary chemokine concentration gradient that allows cell migration via haptotaxis. CCL21 is expressed by endothelial cells of the blood-brain barrier in physiologic and pathologic conditions. CCL21 has also been implicated in leukocyte extravasation into the central nervous system. In this review, we summarize the role of CCL21 in immunosurveillance and explore its potential as an immunotherapeutic agent for the treatment of gliomas. Copyright © 2017 Elsevier B.V. All rights reserved.

Citation

Thien Nguyen, Carlito Lagman, Lawrance K Chung, Cheng Hao Jacky Chen, Jessica Poon, Vera Ong, Brittany L Voth, Isaac Yang. Insights into CCL21's roles in immunosurveillance and immunotherapy for gliomas. Journal of neuroimmunology. 2017 Apr 15;305:29-34