miR-155 as a potential target of IL-3 signaling in primary AML cells.

miR-155 has emerged as one of the key microRNAs (miRNAs) involved in normal and malignant myelopoiesis, and high expression of this miRNA has been flagged as a strong independent prognostic marker in Acute Myeloid Leukemia (AML). While elevated expression of miR-155 has been associated with FLT3-ITD mutations, other mechanisms which may regulate expression of this miRNA in AML remain largely unknown. Here, we present new evidence that miR-155 may be a prime target of IL-3 signaling in primary AML cells. This finding, together with the increasingly apparent role for miR-155 in oncogenesis, and the upregulation of the IL-3 receptor alpha subunit in AML, lead us to propose this pathway may significantly contribute to the leukemic transformation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Citation

Teresa Sadras, Chung H Kok, Michelle Perugini, Hayley S Ramshaw, Richard J D'Andrea. miR-155 as a potential target of IL-3 signaling in primary AML cells. Leukemia research. 2017 Jun;57:57-59

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PMID: 28301819

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