The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.

We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.

Citation

L Sánchez-García, N Serna, M Mattanovich, P Cazzanelli, A Sánchez-Chardi, O Conchillo-Solé, F Cortés, X Daura, U Unzueta, R Mangues, A Villaverde, E Vázquez. The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles. Chemical communications (Cambridge, England). 2017 Apr 20;53(33):4565-4568

PMID: 28322369

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