Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

I S Povarov, R V Kondratenko, V I Derevyagin, N F Myasoedov, V G Skrebitsky

Bulletin of experimental biology and medicine 2017 Mar

filter terms:

Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.

Citation

I S Povarov, R V Kondratenko, V I Derevyagin, N F Myasoedov, V G Skrebitsky. Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons. Bulletin of experimental biology and medicine. 2017 Mar;162(5):640-642