Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells.

Current studies using knockout mice have revealed that some Cys-Cys-Cys-His (CCCH)-type zinc-finger proteins, namely tristetraprolin (TTP), Roquin and Regnase-1, play important roles in the immune system. These proteins are closely associated with the fate of their target RNAs in normal immune responses. However, the functions of many RNA-binding proteins have not been characterized precisely. To understand the molecular mechanisms of RNA metabolism in the immune system, investigation of TTP/Roquin/Regnase-1 might provide new knowledge. In this review, we will discuss the current understanding of these proteins in immune regulation and homeostasis and discuss RNA metabolism in the immune system. © The Author 2017. Published by Oxford University Press on behalf of The Japanese Society for Immunology.

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Kazuhiko Maeda, Shizuo Akira. Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells. International immunology. 2017 Apr 01;29(4):149-155

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PMID: 28369485

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