Preparation and Evaluation of Modified Mohs Paste without Starch.

Maho Taguchi, Masato Shigeyama, Nahomi Ito, Noriko Ogawa, Chisato Takahashi, Mikio Murata, Nobumitsu Hanioka, Hiromitsu Yamamoto, Hitomi Teramachi

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2017

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Mohs paste is an external preparation containing zinc hydrochloride and zinc oxide starch as the main ingredient, and it is used for the palliative treatment of patients with surgically untreatable malignant tumors. However, it has problems, such as changes in hardness and viscoelasticity with time and liquefaction by exudate. To overcome these problems, we modified the formulation of Mohs paste by excluding starch, which is the cause of physical changes, and investigated the base. In the modified Mohs paste using the macrogol ointment for the base, no marked change with time was noted in the hardness, malleability, or elongation property, and the water-absorbing properties were equivalent to those of Mohs paste immediately after preparation. The hardness did not decrease even after absorbing water. The drug release rate increased 1.5 times with the modified Mohs paste. Based on these findings, the risk of liquefaction-associated damage of the surrounding skin decreased on using the modified Mohs paste, and preparing in advance became possible. These results suggest that the modified Mohs paste using the macrogol ointment for the base exhibits an equivalent effect for control of exudate and a high effect for tissue fixation.

Citation

Maho Taguchi, Masato Shigeyama, Nahomi Ito, Noriko Ogawa, Chisato Takahashi, Mikio Murata, Nobumitsu Hanioka, Hiromitsu Yamamoto, Hitomi Teramachi. Preparation and Evaluation of Modified Mohs Paste without Starch. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2017;137(4):477-484