Neolignans and serratane triterpenoids with inhibitory effects on xanthine oxidase from Palhinhaea cernua.

Jing Li, Ping-Sheng Xu, Lei-Hong Tan, Zhen-Xing Zou, Yi-Kun Wang, Hong-Ping Long, Gan Zhou, Guang Li, Kang-Ping Xu, Gui-Shan Tan

Fitoterapia 2017 Jun

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Three new neolignans, lycocernuasides B-D (1-3), three new serratane triterpenoids, lycernuic ketones D (8) and E (9), and lycernuic A (10), together with six known compounds, were isolated from the 75% aqueous EtOH extract of Palhinhaea cernua. Their structures and absolute configurations were established primarily by NMR, HRESIMS and circular dichroism (CD). All compounds were evaluated the inhibitory activities of xanthine oxidase. Compounds 1-3 displayed moderate inhibitory effects on xanthine oxidase with IC50 values of 30.36μM, 42.65μM and 35.33μM, respectively. Copyright © 2017. Published by Elsevier B.V.

Citation

Jing Li, Ping-Sheng Xu, Lei-Hong Tan, Zhen-Xing Zou, Yi-Kun Wang, Hong-Ping Long, Gan Zhou, Guang Li, Kang-Ping Xu, Gui-Shan Tan. Neolignans and serratane triterpenoids with inhibitory effects on xanthine oxidase from Palhinhaea cernua. Fitoterapia. 2017 Jun;119:45-50