Peripherin diverts ciliary ectosome release to photoreceptor disc morphogenesis.

Formation of membrane discs in photoreceptor cells requires evagination of its ciliary plasma membrane by an unknown molecular mechanism. Salinas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608081) show that peripherin (also known as peripherin-2 or peripherin-2/rds) diverts membrane traffic to photoreceptor disc formation by inhibiting ectosome release from the cilium. © 2017 Molday and Goldberg.

Citation

Robert S Molday, Andrew F X Goldberg. Peripherin diverts ciliary ectosome release to photoreceptor disc morphogenesis. The Journal of cell biology. 2017 May 01;216(5):1227-1229

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PMID: 28400442

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